In these kinds of instances, orthopedists may well endorse total joint replacement for your knee, also called knee substitute. 40 Acetaminophen is especially appropriate as first-line therapy in people who are unable to tolerate NSAIDs.fourteen A systematic review of 13 high-good quality RCTs concluded that acetaminophen gives modest small-expression relief https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/