Pentobarbital will decrease the level or effect of vinblastine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of buspirone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 met... https://bookmarkstime.com/story20913413/fascination-circa-pentobarbital-effects