New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the critical enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular entice formation for, to our understanding, the first time. The therapeutic possible of PAD4 inhibitors can now be explored. two. https://helenw111nyi4.dreamyblogs.com/profile